Countries around the world are scrambling to finalise vaccine deals as the global number of coronavirus infections approached 60 million on Wednesday, scientists urged caution and U.S. officials pleaded with Americans to stay home over Thanksgiving.

The holiday weekend is expected to fuel a surge of infections in the United States, which leads the world with soaring COVID-19 infections and the daily toll on Tuesday climbing above 2,000, the highest 24-hour tally since early May.

Hopes for a successful vaccine, boosted by Pfizer, AstraZenica and Moderna, have boosted world stock markets.

But an approved vaccine is unlikely to be widely available for months while scientists insist on the continued need for vigilance as politicians seek to relax curbs for Christmas amid a second wave of the pandemic.

Germany on Wednesday reported a record 410 COVID-19 deaths in the last 24 hours, before its 16 federal state leaders and Chancellor Angela Merkel meet on Wednesday to discuss easing restrictions for the Christmas and New Year holidays.

Italy reported 853 deaths related to COVID-19 on Tuesday, soaring from 630 the day before and the highest daily toll since March 28. But new infections and the number of people in hospital with the virus in France dropped sharply as a national lockdown went into its fourth week.

French President Emmanuel Macron said on Tuesday a vaccine could start being administered by the end of the year.

“We will very likely, and pending authorisation by health authorities, start vaccination of the most vulnerable populations, hence the elderly, as soon as the end of December, early January,” he said in a televised address.

Air France-KLM is among airlines gearing up for the challenge of transporting millions of doses of temperature-sensitive COVID-19 vaccines.

“It’s going to be a major logistics challenge,” said Air France cargo chief Christophe Boucher.

Macron said France will start easing its COVID-19 lockdown this weekend so that by Christmas, shops, theatres and cinemas will reopen and people can spend the holiday with their families.