ENGLAND – A three-year-old boy and seven-year-old girl have been killed in a house fire and a woman has suffered life-changing injuries.

The young children died at the scene in St Neots, Cambridgeshire, and two adults were treated by medics amid a massive emergency response.

A 35-year-old woman suffered life-changing injuries, while a 46-year-old man escaped with minor injuries, officials said.

Flames were shooting out of the three-storey family home in Eynesbury, a suburb of St Neots, when the first fire crews arrived at about 7am on Thursday, CambridgeshireLive reports.

Photos show black scorch marks and smoke damage on an exterior wall and around windows on the first and second floors of the home.